Title

ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration

Authors

Yan Ding
Runzhen Zhao, The University of Texas Health Science Center at Tyler
Xiaoli Zhao
Michael A. Matthay
Hong-Guang Nie
Hong-Long Ji, The University of Texas Health Science Center at TylerFollow

Document Type

Article

Publication Date

Fall 11-27-2017

Abstract

Epithelial sodium channels (ENaC) play an important role in re-absorbing excessive luminal fluid by building up an osmotic Na+ gradient across the tight epithelium in the airway, the lung, the kidney, and the colon. The ENaC is a major pathway for retention of salt in kidney too. MicroRNAs (miRs), a group of non-coding RNAs that regulate gene expression at the post-transcriptional level, have emerged as a novel class of regulators for ENaC. Given the ENaC pathway is crucial for maintaining fluid homeostasis in the lung and the kidney and other cavities, we summarized the cross-talk between ENaC and miRs and recapitulated the underlying regulatory factors, including aldosterone, transforming growth factor-β1, and vascular endothelial growth factor-A in the lung and other epithelial tissues/organs. We have compared the profiling of miRs between normal and injured mice and human lungs, which showed a significant alteration in numerous miRs in mouse models of LPS and ventilator induced ARDS. In addition, we reiterated the potential regulation of the ENaC by miRs in stem/ progenitor cell-based re-epithelialization, and identified a promising pharmaceutic target of ENaC for removing edema fluid in ARDS by mesenchymal stem cells-released paracrine. In conclusion, it seems that the interactions between miRs and scnn1s/ENaCs are critical for lung development, epithelial cell turnover in adult lungs, and re-epithelialization for repair.

Description

© 2017 The Author(s). Published by S. Karger AG, Basel

Persistent Identifier

http://hdl.handle.net/10950/4384

Publisher

S. Karger AG, Basel

Permanent Email Address

hji@uttyler.edu

Recommended Citation

Ding, Yan; Zhao, Runzhen; Zhao, Xiaoli; Matthay, Michael A.; Nie, Hong-Guang; and Ji, Hong-Long, "ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration" (2017). Cellular and Molecular Biology Faculty Publications and Presentations. Paper 5.