Engineered aerosol medicine and drug delivery methods for optimal respiratory therapy

Abstract

The human lung is an effective route for noninvasive drug delivery because it provides a large surface area for rapid absorption, a minimal physical barrier, an absence of extreme pH and metabolism, no first-pass liver, a rich blood supply, and poor bioavailability of oral drugs. The physical and electrical properties of active pharmaceutical ingredient and excipient interactively influence 5 electromechanical deposition mechanisms of respiratory medicinal aerosols while flowing through the airways, including nose, mouth, pharynx, trachea, bronchi, bronchioles, and alveoli.

Description

This article is free to view at the link provided. Copyright © 2014 by Daedalus Enterprises.

Publisher

Respiratory Care Journal

Date of publication

10-2014

Language

english

Persistent identifier

http://hdl.handle.net/10950/4302

Document Type

Article

Publisher Citation

Ali, M. (2014). Engineered aerosol medicine and drug delivery methods for optimal respiratory therapy. Journal of Respiratory Care, 59(10), 1608-1610.

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