Document Type
Poster
Publication Date
2025
Abstract
Introduction: Influenza-induced rhabdomyolysis is a recognized but rare complication of influenza A infection. During the 2009 H1N1 pandemic, several cases of rhabdomyolysis associated with influenza were reported, highlighting the potential for severe extrapulmonary manifestations of the virus.
Case: A 24-year-old African American male with no significant medical history initially presented to a freestanding emergency room with fevers, chills, congestion, and body aches. Subsequently, he tested positive for influenza A and prescribed benzonatate, methocarbamol and promethazine. He returned four days later with persistent severe myalgias and dark urine consistent with rhabdomyolysis and evidenced by a creatine kinase level exceeding 20,000 U/L and myoglobin levels greater than 3,680 ng/mL. Despite aggressive fluid resuscitation, the patient’s renal function deteriorated, necessitating hemodialysis due to volume overload resistant to diuretics. This intervention was successful, and the patient eventually regained kidney function.
Conclusion: Physicians should maintain a high index of suspicion for rhabdomyolysis in patients infected with Influenza A who present with severe myalgias. Given the rarity of rhabdomyolysis in younger populations, it is crucial to consider other etiologies such as trauma, exertion, medications, and metabolic disorders. Early management is essential to prevent complications, including the need for hemodialysis. This involves aggressive fluid resuscitation to maintain adequate urine output. There should be a low threshold to check creatine kinase levels and perform urinalysis to evaluate for possible rhabdomyolysis. Prompt initiation of hemodialysis after failed fluid resuscitation can improve outcomes and reduce morbidity and mortality associated with Influenza A-induced rhabdomyolysis.
Persistent Identifier
http://hdl.handle.net/10950/5163
Journal/Conference Details
Presented at the 2025 UT Tyler School of Medicine Research Day.