Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’- Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, antiadipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences.
This article was originally published in the Journal of Pharmacy & Pharmaceutical Sciences, under a Creative Commons license (Attribution-Share Alike).
Journal of Pharmacy & Pharmaceutical Sciences
Date of publication
Takemoto, Jody K.; Remsberg, Connie M.; and Davies, Neal M., "Pharmacologic Activities of 3’-Hydroxypterostilbene: Cytotoxic, Anti- Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity" (2015). Pharmacy Faculty Publications and Presentations. Paper 1.
Takemoto, J. K., Remsberg, C. M., & Davies, N. M. (2015). Pharmacologic Activities of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity. J Pharm Pharm Sci, 18(4), 713-27.