Abstract
Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’- Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, antiadipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences.
Description
This article was originally published in the Journal of Pharmacy & Pharmaceutical Sciences, under a Creative Commons license (Attribution-Share Alike).
Publisher
Journal of Pharmacy & Pharmaceutical Sciences
Date of publication
2015
Language
english
Persistent identifier
http://hdl.handle.net/10950/637
Document Type
Article
Recommended Citation
Takemoto, Jody K.; Remsberg, Connie M.; and Davies, Neal M., "Pharmacologic Activities of 3’-Hydroxypterostilbene: Cytotoxic, Anti- Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity" (2015). Pharmacy Faculty Publications and Presentations. Paper 1.
http://hdl.handle.net/10950/637
Publisher Citation
Takemoto, J. K., Remsberg, C. M., & Davies, N. M. (2015). Pharmacologic Activities of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity. J Pharm Pharm Sci, 18(4), 713-27.