Event Title
Application of Virus-Like Particles for Cell-Specific Drug Delivery in vitro
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Faculty Mentor
Dr. Ali Azghani
Document Type
Poster Presentation
Date of Publication
2021
Abstract
Muscle atrophy is a prevalent condition that affects millions of individuals with an array of systemic and chronic diseases. As of today, there is no specific treatment to mitigate the effects of muscle atrophy. During this experiment, we utilized human cell lines obtained from the American Type Culture Collection (ATCC), home-constructed virus like particles (VLPs), and fluorescence imaging. The goal of this proposal is to examine the utility of muscle cell receptor-specific VLPs in delivering fluorescein isothiocyanate (FITC) to skeletal muscle cells in vitro. Our working hypothesis is that the specific constructs of VLP can be used to selectively target skeletal muscle tissue for therapeutic delivery.
Keywords
Virus-like particle, cachexia, drug-delivery
Persistent Identifier
http://hdl.handle.net/10950/3048
Delgado_poster
Application of Virus-Like Particles for Cell-Specific Drug Delivery in vitro
Muscle atrophy is a prevalent condition that affects millions of individuals with an array of systemic and chronic diseases. As of today, there is no specific treatment to mitigate the effects of muscle atrophy. During this experiment, we utilized human cell lines obtained from the American Type Culture Collection (ATCC), home-constructed virus like particles (VLPs), and fluorescence imaging. The goal of this proposal is to examine the utility of muscle cell receptor-specific VLPs in delivering fluorescein isothiocyanate (FITC) to skeletal muscle cells in vitro. Our working hypothesis is that the specific constructs of VLP can be used to selectively target skeletal muscle tissue for therapeutic delivery.
Comments
sandra Jimenez commented "This is great. I keep coming back to it, it's so good."