Event Title

Developing the HK97 Virus-Like Particle as a Drug Delivery System

Presenter Information

J. Michael King

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Lyceum Winners

First Place - Outstanding Undergraduate Oral Presentation

Document Type

Oral Presentation

Date of Publication

4-17-2020

Abstract

Protein cage structures are ubiquitous in nature and present useful nanomaterials for applications ranging from drug delivery to the construction of nanoelectronics. Among protein cages, virus-like particles (VLPs), which are derived from the protein shell or capsid of viruses but lack pathogenic components, are particularly intriguing for constructing nanomaterials due to their stability, well studied molecular assembly and structures, which are often characterized to the molecular level. The research presented looks at developing the VLP derived from the HK97 bacteriophage for loading large quantities of small molecule cargoes on the VLP interior and external modification to provide cell-specific targeting for drug delivery applications.

Keywords

virus, drug delivery, biology, HK97

Persistent Identifier

http://hdl.handle.net/10950/2516

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Apr 17th, 12:00 AM Apr 17th, 12:00 AM

Developing the HK97 Virus-Like Particle as a Drug Delivery System

Protein cage structures are ubiquitous in nature and present useful nanomaterials for applications ranging from drug delivery to the construction of nanoelectronics. Among protein cages, virus-like particles (VLPs), which are derived from the protein shell or capsid of viruses but lack pathogenic components, are particularly intriguing for constructing nanomaterials due to their stability, well studied molecular assembly and structures, which are often characterized to the molecular level. The research presented looks at developing the VLP derived from the HK97 bacteriophage for loading large quantities of small molecule cargoes on the VLP interior and external modification to provide cell-specific targeting for drug delivery applications.