Abstract
The SARS-CoV-2 virus has evolved throughout the pandemic and is likely to continue evolving into new variants. Some of these variants may affect functional properties, including infectivity, interactions with host immunity, and disease severity. And compromised vaccine efficacy is an emerging concern with every new viral variant. Next-generation sequencing (NGS) has emerged as the tool of choice for discovering new variants and understanding the transmission dynamics of SARS-CoV-2. Deciphering the SARS-CoV-2 genome has enabled epidemiological survivance and forecast of altered etiologically. Clinical presentations of the infection are influenced by comorbidities such as age, immune status, diabetes, and the infecting variant. Thus, clinical management and vaccine efficacy may differ for new variants. For example, some monoclonal antibody treatments are variantspecific, and some vaccines are less efficacious against the omicron and delta variants of SARS-CoV-2. Consequently, determining the local outbreaks and monitoring SARS-CoV-2 Variants of Concern (VOC) is one of the primary strategies for the pandemic’s containment. Although next-generation sequencing (NGS) is a gold standard for genomic surveillance and variant discovery, the assays are not approved for variant diagnosis for clinical decision-making. Advanta Genetics, Texas, USA, optimized Illumina COVID-seq protocol to reduce cost without compromising accuracy and validated the Illumina COVID-Seq assay as a Laboratory Developed Test (LDT) according to the guidelines prescribed by the College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA).
Description
This article is published in Data in Brief under a Creative Commons BY license (http://creativecommons.org/licenses/by/4.0/).
Publisher
Elsevier
Date of publication
Summer 6-14-2023
Language
english
Persistent identifier
http://hdl.handle.net/10950/4234
Document Type
Article
Recommended Citation
Carpenter, Rob E.; Tamrakar, Vaibhav K.; and Advanta Genetics, "SARS-CoV-2 Next Generation Sequencing (NGS) data from clinical isolates from the East Texas Region of the United States" (2023). Human Resource Development Faculty Publications and Presentations. Paper 31.
http://hdl.handle.net/10950/4234
Publisher Citation
Carpenter, R. E., Tamrakar, V. K., Almas, S., Sharma, A., & Sharma, R. (2023). SARS-CoV-2 Next Generation Sequencing (NGS) data from clinical isolates from the East Texas Region of the United States. Data in Brief, 109312.