Abstract

Deep learning classifiers deployed in clinical settings routinely issue overconfident predictions on ambiguous or out-of-distribution inputs, posing a significant patient safety risk. This thesis proposes a post-hoc geometric abstention framework that extends the circular prototypical space approach of Dakshit (2024) by replacing the spherically symmetric boundary with a convex hull a shape-adaptive polytope that exactly encloses the true positive training embeddings of each class. The framework requires no retraining or modification of base model weights and is applicable to any pre-trained deep neural network classifier. Embeddings are extracted and projected via truncated Singular Value Decomposition into spaces of 2, 6, and 8 dimensions. A convex hull is constructed per class from correctly classified training samples, and a validation sweep identifies optimal hull expansions under nonoverlap or subtraction assignment, verified via linear programming feasibility. The framework is evaluated on three medical datasets a one-dimensional ECG rhythm dataset, a two-dimensional ECG image dataset, and a multiclass chest radiograph dataset using a custom Rhythm CNN, EfficientNetB0, and VGG16 respectively. On the ECG 1D task, the method achieves 100% retained accuracy with complete error elimination at 6D, deferring 34.9% of samples. On the chest radiograph task, the 8D projection achieves the lowest deferral rate (18.7%) and highest retained accuracy (99.71%) with 80% error improvement. On the ECG 2D task, geometric inseparability constrains the system to subtraction mode, yielding meaningful but more modest gains. These results establish convex hull prototypical spaces as a principled, interpretable, and clinically deployable foundation for selective prediction in medical AI.

Date of publication

Spring 2026

Document Type

Dissertation

Language

english

Persistent identifier

http://hdl.handle.net/10950/5051

Committee members

Dr. Yi Li , Dr. Arun Kulkarni , Dr. Sagnik Dakshit , Dr. Leonard Brown

Degree

Master of Science in Computer Science

Available for download on Thursday, April 27, 2028

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