Abstract
Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this article focuses on documenting current knowledge in the abundance and distribution of somatic mitochondrial mutations, followed by elucidation of processes which affect the fate of mutations in cancer cells. The conclusion includes an overview of translational implications for mtDNA mutations, as well as recommendations for future research uniting mitochondrial variants and tumorigenesis.
Description
Copyright © 2017 Hertweck and Dasgupta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publisher
Frontiers Media SA
Date of publication
Fall 11-2-2017
Language
english
Persistent identifier
http://hdl.handle.net/10950/4376
Document Type
Article
Recommended Citation
Hertweck, Kate L. and Dasgupta, Santanu, "The landscape of mtDNA modifications in cancer: A tale of two cities" (2017). Biology Faculty Publications and Presentations. Paper 34.
http://hdl.handle.net/10950/4376