Abstract
The blood-cerebrospinal fluid boundary is present at the level of epithelial cells of the choroid plexus. As one of the sources of the cerebrospinal fluid (CSF), the choroid plexus (CP) plays an important role during brain development and function. Its formation has been studied largely in mammalian species. Lately, progress in other model animals, in particular the zebrafish, has brought a deeper understanding of CP formation, due in part to the ability to observe CP development in vivo. At the same time, advances in comparative genomics began providing information, which opens a possibility to understand further the molecular mechanisms involved in evolution of the CP and the blood-cerebrospinal fluid boundary formation. Hence this review focuses on analysis of the CP from developmental and evolutionary perspectives.
Description
Copyright © 2014 Bill and Korzh. This is an open-access article distributed under theterms of the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) or licensorare credited and that the original publication in this journal is cited, in accordance withaccepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publisher
Frontiers Media SA
Date of publication
Fall 11-14-2014
Language
english
Persistent identifier
http://hdl.handle.net/10950/4361
Document Type
Article
Recommended Citation
Bill, Brent Roy and Korzh, Vladimir, "Choroid plexus in developmental and evolutionary perspective" (2014). Biology Faculty Publications and Presentations. Paper 19.
http://hdl.handle.net/10950/4361