Central line-associated bloodstream infections (CLABSIs) are among the most frequent health care-associated infections and are reported to be correlated with an increased number of inpatient days, higher cost, and attributable mortality rates (Devrim et al., 2016). For this reason, central line bundles (CLB) have been widely used in hospitals to aid in the decrease of CLABSIs. Through implementation of the prevention strategies included in CLBs, CLABSIs can be reduced by greater than fifty percent (Devrim et al., 2016). A decrease in CLABSIs is clinically significant with the avoidance of negative patient outcomes and a decrease in healthcare costs (Rinke et al., 2013).

Approximately 85% of pediatric hematology/oncology patients have long-term central venous access catheters, which places them at an extremely high risk for CLABSIs (Devrim et al., 2018). CLABSIs are increasingly recognized as a preventable health care-associated infection (Ziegler et al., 2015). This indicates that nurses, patients, and their families all play a crucial role in minimizing the risk of central line-associated bloodstream infections. Compliance with performing all components in a CLB is a significant factor in the decrease of CLABSI incidence rates (Devrim et al., 2018). By understanding the importance of CLB, especially in the pediatric hematology/oncology population, an increase in CLABSIs can be avoided and patients’ quality of life can be improved. The PICOT question that will be used for this best practice project is: On a pediatric oncology unit (P), does adherence to a central-line bundle (I) compared to non-adherence (C) prevent or reduce (O) central line-associated bloodstream infections within 12 weeks (T)?

Date of publication

Spring 4-23-2024

Document Type

MSN Capstone Project



Persistent identifier



Masters of Science in Nursing