This project is on enhancing pain management in total knee arthroplasty (TKA) clients via the intravenous (IV) administration of acetaminophen (Ofirmev) by multimodal regimen. The patient, intervention, comparison, outcome, and time (PICOT) question shaping this initiative looks at frequency and intensity of patients’ pain scores as well as practical outcome measures such as healing and physical therapy during the recovery period ending with discharge. After a thorough literature synopsis, it is evident that multimodal pain management strategies including IV acetaminophen provide a better prospectus in comparison to the ones that solely employ opioids. Research repeatedly demonstrates the use of IV acetaminophen used in a supplemental manner for patients after TKA surgery results in less opioid consumption, improved pain control, enhanced functional outcomes, and shorter hospital stays for patients who receive such treatment. This evidence clearly underpins the imperativeness of multi-modality strategies using IV acetaminophen to ensure the best care and speed up recovery post-operatively after TKA. Apart from patients and their families, the health administrators, nurses, and physical therapists play a crucial role in providing care during the perioperative period. Implementation plans embrace education and training for nursing staff, development of protocols, interdisciplinary collaborations, patient education and monitoring process, and inclusion of evaluating processes. Data will be collected through pre- and postoperative pain scores, opioid intake monitoring, functional outcomes assessment, length of stay in hospital and patient satisfaction forms. Outcome analysis will use descriptive, inferential, and cost/benefit statistics to evaluate data while determining the economic impact of each measure.

Date of publication

Spring 4-20-2024

Document Type

MSN Capstone Project



Persistent identifier



Master's of Science in Nursing

Adding ofirmev.pdf (1502 kB)
Power Point Dissertation