Non-healing wounds are a growing global public health concern due to inadequate or ineffective therapeutic products available. Cellulose-based biopolymers are attractive wound dressing materials due to their biocompatibility, biodegradability, non-toxicity, and cost-effectiveness. This study aims to design and fabricate solid dosage formulations using carboxymethyl cellulose (CMC) and ethyl cellulose (EC) to facilitate multi-stage releases of phenytoin (PHT) and tetracycline hydrochloride (TCH) from plain carriers, fibers/films composites, and layer-by-layer fiber composites. Results from in vitro drug release assays demonstrated a time-dependent release up to 8 hours from PHT-loaded EC fibers, while TCH-loaded CMC films exhibited a rapid release within 5 minutes. In fiber-in-film composites, EC fibers were encapsulated in CMC films resulting in slow release of PHT, while hydrophobic EC fibers protected TCH release from CMC films within 5 hours in fiber-on-film composites. Drug release from layer-by-layer fiber composites showed dependence on composite arrangements and core/shell flow rate ratios. In general, through the understandings of drug releases from EC fibers and CMC films, fibers/films composites and layer-by-layer fibers composites were fabricated to provide a solution in customizable multi-stage drug release in drug delivery for wound healing applications.

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