Abstract

Electrospun fibers have attracted attentions in topical drug delivery due to the ability to modulate drug release at high drug loading. While the pharmaceutical properties of these drug-eluting fibers were reported elsewhere, the compatibility of these fibers with hydrogen peroxide vapor, an effective decontaminant, is not fully established. In this work, polylactic acid (PLA) microfibers loaded with acetylsalicylic acid (ASA) were electrospun to examine their compatibility with hydrogen peroxide vapor. Results suggested a strengthening effect of the PLA/ASA fibers due to intermolecular interactions of ASA with PLA, which modulated the in vitro drug release rates. After exposing PLA/ASA fibers to vapor phase hydrogen peroxide, results showed the disruptions of the intermolecular bonds between the ASA and PLA that reduced the mechanical properties and facilitated the burst release behaviors of the fibers. This work provided the scientific understanding on the role of drug-polymer interactions in electrospun fibers and their corresponding effects after exposure to hydrogen peroxide vapor.

Date of publication

Fall 12-10-2021

Document Type

Thesis

Language

english

Persistent identifier

http://hdl.handle.net/10950/3837

Committee members

Shin-Feng Chou, Ph.D., Fredericka Brown, Ph.D., Nelson Fumo, Ph.D.

Degree

Mechanical Engineering

Available for download on Sunday, December 10, 2023

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