Event Title

Application of Virus-Like Particles for Cell-Specific Drug Delivery in vitro

Presenter Information

Mercedes Delgado

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Faculty Mentor

Dr. Ali Azghani

Document Type

Poster Presentation

Date of Publication

2021

Abstract

Muscle atrophy is a prevalent condition that affects millions of individuals with an array of systemic and chronic diseases. As of today, there is no specific treatment to mitigate the effects of muscle atrophy. During this experiment, we utilized human cell lines obtained from the American Type Culture Collection (ATCC), home-constructed virus like particles (VLPs), and fluorescence imaging. The goal of this proposal is to examine the utility of muscle cell receptor-specific VLPs in delivering fluorescein isothiocyanate (FITC) to skeletal muscle cells in vitro. Our working hypothesis is that the specific constructs of VLP can be used to selectively target skeletal muscle tissue for therapeutic delivery.

Keywords

Virus-like particle, cachexia, drug-delivery

Persistent Identifier

http://hdl.handle.net/10950/3048

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Application of Virus-Like Particles for Cell-Specific Drug Delivery in vitro

Muscle atrophy is a prevalent condition that affects millions of individuals with an array of systemic and chronic diseases. As of today, there is no specific treatment to mitigate the effects of muscle atrophy. During this experiment, we utilized human cell lines obtained from the American Type Culture Collection (ATCC), home-constructed virus like particles (VLPs), and fluorescence imaging. The goal of this proposal is to examine the utility of muscle cell receptor-specific VLPs in delivering fluorescein isothiocyanate (FITC) to skeletal muscle cells in vitro. Our working hypothesis is that the specific constructs of VLP can be used to selectively target skeletal muscle tissue for therapeutic delivery.