Design of Innovative Perfusion System for In-Vitro Drug Perfusion System.

A perfusion system is used by researchers to test the effects of chemical libraries in a potential biological target. This project is aimed at developing a medium throughput perfusion and drug exchange system for drugs testing under conditions that simulate normal biological conditions. The proposed system is governed by a computer-based control system that will allow for remote operation and control via secured access. Moreover, the proposed perfusion system will allow testing of a wide spectrum of the circulatory fluid compositions, through controlled addition of drugs, and accurate monitoring of its effect on living cells. Furthermore, the proposed system is expected to improve the throughput of current research in pharmaceutical drug screening to find a therapy for drug addiction, while enhancing the infrastructure of collaborative research at UT Tyler. Initial design data and test results are presented here, while the complete design and characterization results will be disseminated upon completion of the project.