Event Title
Developing the HK97 Virus-Like Particle as a Drug Delivery System
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Lyceum Winners
First Place - Outstanding Undergraduate Oral Presentation
Document Type
Oral Presentation
Date of Publication
4-17-2020
Abstract
Protein cage structures are ubiquitous in nature and present useful nanomaterials for applications ranging from drug delivery to the construction of nanoelectronics. Among protein cages, virus-like particles (VLPs), which are derived from the protein shell or capsid of viruses but lack pathogenic components, are particularly intriguing for constructing nanomaterials due to their stability, well studied molecular assembly and structures, which are often characterized to the molecular level. The research presented looks at developing the VLP derived from the HK97 bacteriophage for loading large quantities of small molecule cargoes on the VLP interior and external modification to provide cell-specific targeting for drug delivery applications.
Keywords
virus, drug delivery, biology, HK97
Persistent Identifier
http://hdl.handle.net/10950/2516
Developing the HK97 Virus-Like Particle as a Drug Delivery System
Protein cage structures are ubiquitous in nature and present useful nanomaterials for applications ranging from drug delivery to the construction of nanoelectronics. Among protein cages, virus-like particles (VLPs), which are derived from the protein shell or capsid of viruses but lack pathogenic components, are particularly intriguing for constructing nanomaterials due to their stability, well studied molecular assembly and structures, which are often characterized to the molecular level. The research presented looks at developing the VLP derived from the HK97 bacteriophage for loading large quantities of small molecule cargoes on the VLP interior and external modification to provide cell-specific targeting for drug delivery applications.